Anaplastic Lymphoma Kinase

A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.

Also Known As:

ALK Kinase; ALK Tyrosine Kinase Receptor; Anaplastic Lymphoma Receptor Tyrosine Kinase; CD246 Antigen; NPM-ALK; Nucleophosmin-Anaplastic Lymphoma Kinase; Nucleophosmin Anaplastic Lymphoma Kinase

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9899
        Protein-Tyrosine Kinases: 7827
        Receptor Protein-Tyrosine Kinases: 6127
        Anaplastic Lymphoma Kinase: 3851
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Cell Surface Receptors: 2156
      - Receptor Protein-Tyrosine Kinases: 6127
        Anaplastic Lymphoma Kinase: 3851
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7827
      - Receptor Protein-Tyrosine Kinases: 6127
        Anaplastic Lymphoma Kinase: 3851

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Disease

Drug/Important Bio-Agent (IBA)